Question 1
A 55-year-old obese male presents with a blood pressure of 155/95 mmHg despite adherence to dual antihypertensive therapy. He complains of frequent morning headaches and falling asleep during daytime meetings. His partner reports that he snores loudly every night. His basic metabolic panel and urinalysis are normal. Which secondary hypertension cause is most likely?
βΈ Why A is the answer
This patient's presentation of resistant hypertension, obesity, morning headaches, and significant daytime somnolence points directly to obstructive sleep apnea as the secondary cause. The repeated nocturnal hypoxic episodes trigger sympathetic nervous system surges, leading to sustained blood pressure elevation that is notoriously difficult to control. Renal artery stenosis might cause resistant hypertension but would typically present with an abdominal bruit or declining renal function, not profound daytime sleepiness. Adrenal medullary pheochromocytoma causes episodic hypertension with sweating and palpitations, rather than the chronic fatigue and snoring seen here. Primary adrenal hyperaldosteronism presents with resistant hypertension but is distinguished by hypokalemia and muscle weakness, which are absent in this patient's normal metabolic panel.
π Key takeaway
Resistant hypertension paired with obesity, morning headaches, and daytime somnolence strongly suggests obstructive sleep apnea.